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Three of the most widely used serotonin supplements are the amino acids tryptophan, 5-HTP, and SAM-e.

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

Do so only if you are working with a knowledgeable health care professional. Tryptophan: Tryptophan might seem like a logical serotonin supplement to try first since tryptophan is a precursor of serotonin.

Together, they can cause too large an increase in serotonin, which can result in a potentially serious condition known as serotonin syndrome. Tryptophan is an amino acid commonly found in protein-rich foods like animal products.

If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.

There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.

All of the B vitamins are needed for a healthy, functioning nervous system and several are needed to synthesize serotonin (16).

Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.

Elsewhere in Europe, it’s available as a prescription drug (8).

Unfortunately, this supplement’s usefulness for depression may be more hype than substance.

5-HTP (5-hydroxytryptophan): 5-HTP could be considered as either an amino acid or herbal supplement.

It comes from Griffonia simplicifolia, an African woody shrub. But we’ve put it in the amino acid category since it’s so closely associated with tryptophan. S., Canada, and the United Kingdom, 5-HTP is sold as an over-the-counter supplement for ADHD, anxiety, depression, fibromyalgia, migraines, sleep disorders, and weight loss (7).

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